New vaccine for Chlamydia to use synthetic biology

  • Posted on 3 August, 2015
We are delighted to announce that Prokarium Ltd, a biotechnology company developing transformational oral vaccines, will today receive new funding from SynbiCITE.

The £498k project is funded at £377k from SynbiCITE and £121k from Prokarium and will enable Prokarium and its collaborator Prof Robin Shattock of Imperial College to complete the pre-clinical development of an innovative Chlamydia vaccine which could enter clinical trials in 2017.

With 92 million new cases of Chlamydia worldwide and over 200,000 new cases in the UK per year, Chlamydia is one of the most common sexually transmitted infections in the world. Symptoms can be serious including pelvic inflammatory disease that can lead to infertility and, in children infected by their mothers, even blindness.

According to Dr Ted Fjällman, CEO of Prokarium, “the new vaccine uses synthetic biology to make the first safe and effective Chlamydia vaccine since the 1960s when conventional methods revealed unacceptable side effects and clinical efforts were abandoned. We have produced a carrier in the form of a re-engineered strain of Salmonella containing the blueprint for the vaccine. It will be taken orally and as it enters through the person’s gut lining it is naturally engulfed by the body’s own immune cells and only then triggered to produce the active vaccine exactly where it is needed and without side effects in other parts of the body. This is a uniquely suitable solution and has already raised interest from big pharmaceutical companies.”

The new Prokarium vaccine was selected for funding because the need for a Chlamydia vaccine is significant and the potential for this approach both for Chlamydia and as a model for treating other infections in the medium-term is very encouraging.

– Dr Steve Chambers, CEO of SynbiCITE

A National Chlamydia Screening Programme report[1] shows NHS spending of £45 per person on screening for Chlamydia and it is expected that a mass vaccination programme for 10-14 year olds would cost significantly less.

Dr Steve Chatfield, Chairman of Prokarium and former Executive Director of the UK Health Protection Agency, says: “This SynbiCITE funding allows us to test a vaccine against the one of the world’s most serious sexually transmitted infections. This endeavour, amongst others, has also enabled us to attract Dr Allan Jarvis, former Vice President of Corporate Development of Sanofi Pasteur to Prokarium’s Board of Directors. Prokarium is now well set up to work with the best of the best in the vaccine arena.”

1. Guidance for the commissioners on the cost of providing chlamydia screening in primary care and the community: a review of costs in practice across England in 2009. Prepared by the National Chlamydia Screening Programme, December 2009